The Future of Cell and Gene Therapy
As cell and gene therapy (CGT) continues to evolve, the demand for solutions to address production, transportation, and storage challenges has never been greater. We understand the critical role that advanced engineering and automation play in unlocking the full potential of these life-changing therapies. Our recently released whitepaper, “Cell & Gene Therapy,” examines the technical challenges and promising solutions shaping the future of this exciting field.
Overcoming Cryopreservation Challenges
Cryopreservation is a crucial aspect of CGT, ensuring the viability of live drugs during extended storage. However, the application of cryopreservation at scale presents unique challenges. Our whitepaper explores engineering considerations, such as cryocontainer design, cooling and thawing rates, and achieving Good Manufacturing Practice (GMP) at scale.
We explain how our multiphysics simulation capabilities and expertise in optimising full-scale production lines position us to support the development of cryovessel solutions. By using our advanced testing facility and simulation tools, we can efficiently verify and validate new scale-up cryocontainer designs, accelerating their mainstream adoption.
Embracing Automation for Scaled CGT Production
As CGT production scales up, maintaining GMP compliance while improving efficiency and consistency becomes essential.
Our whitepaper examines the role of automation in enhancing GMP compliance, reducing manual handling risks, and optimising the scalability of CGT manufacturing.
We explore the evolution of automation systems, from first-generation robotic assistance to second-generation advanced platforms like the Cellares Cell Shuttle. Our extensive experience in modelling and optimising production lines and our Human Factors team’s expertise in usability assessments position us to help clients navigate the complexities of integrating automation into their CGT workflows.
Tackling Real-World Challenges: A Case Study
The whitepaper presents a case study highlighting the impact of cold chain storage on the mechanical performance of a pre-filled syringe (PFS) container closure system. We demonstrate how our high-fidelity medical device digital twins, underpinned by rich physical test data, can accurately predict container closure integrity (CCI) across various design variants, materials, tolerances, and storage conditions.
Your Partner in Advancing CGT
As the CGT landscape evolves, we remain committed to pioneering innovative solutions that address the field’s most pressing challenges.
Download the Whitepaper Today
In our whitepaper, you will:
- Gain insights into the engineering challenges and solutions in cryopreservation for CGT applications
- Understand the role of automation in maintaining GMP compliance and scaling CGT production
- Learn how our high-fidelity digital twins can de-risk the development of CGT products and assess the suitability of existing container solutions
Download our whitepaper “Cell & Gene Therapy” to begin understanding the potential of these transformative therapies.
